Understand Disease Mechanisms, Apply Knowledge, and Think Like a Clinician.

About This Text

This concise, well-organized text links normal physiology to the pathophysiology of common disorders and shows how mechanisms guide diagnostics and management. Learn why patients present with specific symptoms, how to interpret results, and how to translate science into clinical decisions. Includes case studies, more than 500 images, and end-of-chapter key points.

Enhance understanding and application of content with CourseConnect

CourseConnect is an interactive learning platform that provides focused lessons, practice quizzes, case studies, and progress tracking so you always know what to review next. Print copies include a CourseConnect access code.

What’s New in the Second Edition

Physiology of pregnancy, labor, and delivery
Expanded neonatal and pediatric development section
Cell-free DNA methylation (epigenetics) patterns in oncology
Expanded fluid and electrolyte balance section
Enhanced section on the social determinants of health
Introduction of the exposome concept in human disease
Updates on biological and psychosocial aspects of sexual development, including LGBTQ+-centered care

Why Students Love This Text

Clear, concise content connects physiology to pathophysiology and real-life care
Bridge to Clinical Practice sections help translate concepts to practical patient care.
Over 500 full-color images illustrate and simplify complex ideas
Case studies and critical-thinking questions build clinical decision-making skills
Chapter summaries and key points reinforce learning
Comprehensive lifespan coverage from pediatric to geriatric care

Get it with CourseConnect: the Smarter Way to Succeed.

Included with your print purchase. CourseConnect is an interactive learning platform that helps you learn faster, study smarter, retain more, and feel confident on exam day. Go beyond the book with tools that help you learn, apply, and assess your progress anywhere, anytime.

Bite-sized interactive lessons for focused, efficient study
Applied scenarios that connect concepts to practice
Quizzes and flashcards with instant feedback
Personal dashboard to track strengths, gaps, and progress
Study tools, including notes, bookmarks, and search
Expert-powered AI assistant offering instant, trusted guidance anytime you need it

Print books include a CourseConnect access code inside the front cover. Continuous is for the life of the product edition, plus one year.