Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an essential resource for pathologists at all levels of experience and training. Designed for both quick reference and in-depth review, it features a highly accessible, point-of-care format with templated, bulleted content supported by charts, graphs, tables, and full-color photomicrographs of histology with special stains. The text provides a practical, clinically focused approach to understanding how molecular mutations influence disease and explains the appropriate molecular tests required for a comprehensive diagnostic evaluation in the era of molecular-targeted therapies.
Updated coverage of molecular mutations across a wide range of tumors, including solid tumors and hematopoietic neoplasms, along with the latest targeted therapies developed for these molecular alterations.
Comprehensive discussion of widely used immunotherapy treatments and how they have transformed the management of many cancers, including breast and lung carcinomas and lymphoma.
More than 2,000 annotated images throughout the text, including H&E stains, immunostains, and FISH images.
Coverage includes:
Recent advances in cancer immunotherapy, with emphasis on the molecular basis of immunotherapeutic approaches.
Newly developed targeted therapies, including multiple treatment options for lung carcinoma based on mutations in genes such as KRAS, ALK, BRAF, and ROS.
Integration of myeloid and lymphoid gene panels driven by discoveries from next-generation sequencing and the identification of new molecular targets.
Expanded use and applications of next-generation sequencing (NGS) techniques.
Updated hematopoietic tumor classifications reflecting revised WHO guidelines.
Recognition as the recipient of the 2016 BMA Award: Highly Commended, Pathology (previous edition).